Estrés oxidativo en ciclo celular
Nuestro grupo está formado por un entusiasta grupo de investigadores, cuyo principal interés es la caracterización de las respuestas celulares al estres oxidativo y el control del ciclo celular en el proceso de fisión de la levadura, Schizosaccharomyces pombe, usando aproximaciones novedosas en biología molecular, proteomiica, espectrofotometria y de imagen
Publicaciones Recientes
- Phospho-mimicking Atf1 mutants bypass the transcription activating function of the MAP kinase Sty1 of fission yeast. Curr. Genetics. 2017
- Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation. J Biol Chem 2017, 292 (33):13635-13644
- Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase. PLoS Genet. 2017: 13 (6): e1006858
- Proteomic Characterization of Reversible Thiol Oxidations in Proteomes and Proteins.Antioxidants Redox and Signaling 2017 26(7):329-344
- A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism. Cell Rep. 2016;16(7):1891-902.
- A functional genome-wide genetic screening identifies new pathways controlling the G1/S transcriptional wave. Cell Cycle 15:720-72.
- Spatiotemporal control of forkheads binding to DNA regulates the meiotic gene expression program. Cell Reports 14:885-895.
- Prp4 kinase grants the license to splice: control of weak splice sites during spliceosome activation. PLoS Genet. 12(1):e1005768.
- Genome-wide Screening of Regulators of Catalase Expression: Role of a Transcription Complex and Histone and tRNA Modification Complexes on Adaptation to Stress. J. Biol. Chem. 291:790-799.
- Distinct biological activity of threonine monophosphorylated MAPK isoforms during the stress response in fission yeast. Cell Signal. 27:2534-2542.
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