Bioenergetics and oxidative stress in the nervous system
This group is interested in understanding the molecular mechanisms that regulate the energetic and redox homeostasis in the cells of the central nervous system. In particular, they study the proteins and signaling pathways responsible for the adaptation of the neuronal metabolism to the continuous and high energetic and antioxidant demand imposed by neurotransmission.
Besides the advance in knowledge, the potential results of this research line would allow to identify specific metabolic targets, which genetic alterations contribute to neurotransmission malfunctioning and cause many neurological problems, including neurodegenerative diseases.
Recent Publications
- Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants. Neurochem Int, 2017
- APC/CCdh1-Rock2 pathway controls dendritic integrity and memory. Proc Natl Acad Sci U S A. 2017;114(17):4513-4518
- Mitochondrial Complex I Activity is Conditioned by Supercomplex I-III2-IV Assembly in Brain Cells: Relevance for Parkinson's Disease. Neurochem Res. 2017; 42(6):1676-1682.
- α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list: An Editorial highlight for 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?J Neurochem. 2016;139(5):689-690. '
- Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. Cardiovasc Diabetol 2016; 15(1):82.
- Mitochondrial control of cell bioenergetics in Parkinson's disease. Free Radic Biol Med. 2016.
- Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells. Free Radic Biol Med. 2015;87:226-36
- Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons. Sci Rep. 2015.; 5:18180.
- Bioenergetics and redox adaptations of astrocytes to neuronal activity. J Neurochem. 2016
- NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Rep. 2016; 14(8): 1883-91
- Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging.Front Aging Neurosci. 2015; 7:89.
- Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway. Cell Death Differ. 2015;22(11):1877-89
- DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1. Biochem J. 2015: 467 (2): 303-10
- Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival. J Neurosci. 2015; 35(25):9287-301.
Address
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Instituto de Biología Funcional y Genómica (IBFG). Zacarias González, 2 Laboratorio 2.7 37007 Salamanca