Metabolic dysfunction and mitochondrial oxidative stress in disease
Metabolic syndrome is associated with an increased risk of developing an important number of pathologies, ranging from cardiovascular disease to cancer. Due to the pandemic character of the metabolic syndrome and it has and it poses overwhelming social and heath care burden. Therefore, it is necessary to elucidate the mechanisms that undertay that increased disease risk and to develop appropiate paliating therapies
The transcriptional coactivator PGC-1ais a master regulator of oxidative metabolism, and is also responsible for the regulation of esential stress genes. The aim of this group is to evaluate the role of PGC-1a in the metabolic dysfunctions related to the capacity of the organism to respond to an vast array of insults and hence increases the risk of disease. understand the mechanisms involved and develop new therapeutical tools based on the target specific activation of PGC-1
Recent Publications
- Heme-Oxygenase I and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987.Antioxidants Redox and Signalling 2017: 93-105
- PGC-1α Downregulation in Steatotic Liver Enhances Ischemia-Reperfusion Injury and Impairs Ischemic Preconditioning. Redox Biology 2017:1020-1025
- ROS homeostasis, a key determinant in liver ischemic-preconditioning. Redox Biology 2017:1020-1025
- Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice.Angiogenesis 2016, 19(2) 217-28
- Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling Free Radical Biol Med 2016: 93:41-51.
- The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury. Kidney Int 2016, 89 (2):399-410
- mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery.Anatol J Cardiol. 2016, 16 (8): 622-629
- Redox regulation of FoxO transcription factors. Redox Biol. 2015; 6:51-72.
- Blood PGC-1α Concentration Predicts Myocardial Salvage and Ventricular Remodeling After ST-segment Elevation Acute Myocardial Infarction. Rev Esp Cardiol (Engl Ed). 2015; 68(5):408-16.
- SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex.Antioxid Redox Signal. 2013; 19(13):1507-21
Address
IP: Maria P. Monsalve Perez, This email address is being protected from spambots. You need JavaScript enabled to view it. 915854471 Instituto de Investigaciones Biomédicas. Alberto Sols. Arturo Duperier 4. 28029 Madrid