Oxidative stress in yeast
The main objective of this research group is to analyze the impact of oxidative stress on cellular functions. Regarding that topic, the production of reactive oxygen species and oxidative damage in macromolecules is analyzed. Relying on two types of models; yeasts and primary cultures of cardiomyocytes and neurons and with proteomic approaches we study deregulation of iron metabolism. More specifically we analyze the relationship between oxidative stress and the accumulation of intracellular iron produced in frataxin deficient cells following the macromolecular damage. These processes appear in some human diseases. This is the case of Friedrich's Ataxia.
Recent publications
- Reversible glutathionylation of Sir2 by monothiol glutaredoxins Grx3/4 regulates stress resistance. Free Radic Biol Med. 2016; 96:45-56.
- Impaired PLP-dependent metabolism in brain samples from Huntington disease patients and transgenic R6/1 mice. Metab Brain Dis. 2016;31(3):579-86.
- Cth2 Protein Mediates Early Adaptation of Yeast Cells to Oxidative Stress Conditions. PLoS One. 2016 J;11(1):e0148204.
- Impaired mitochondrial Fe-S cluster biogenesis activates the DNA damage response through different signaling mediators. J Cell Sci. 2015; 128(24):4653-65.
- Oxidative stress and altered lipid metabolism in Friedreich ataxia.Free Radic Biol Med. 2016
- Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism. Free Radic Biol Med. 2014;73:21-33.
- Apoptotic cell death and altered calcium homeostasis caused by frataxin depletion in dorsal root ganglia neurons can be prevented by BH4 domain of Bcl-xL protein. Hum Mol Genet. 2014; 23(7):1829-41.
- Protein carbonylation: proteomics, specificity and relevance to aging.33(1):21-48
- Memory impairment and hippocampus specific protein oxidation induced by ethanol intake and 3, 4-methylenedioxymethamphetamine (MDMA) in mice. J Neurochem. 2013;125(5):736-46.
Address This email address is being protected from spambots. You need JavaScript enabled to view it.Universidad de Lleida. IRB Lleida. Dpto CC Biomédicas. Fac de Medicina Avenida Rovira Roura, 80. Edificio Biomedicina Lleida. 973702275