Functional genetics of the oxidative phosphorylation system
This laboratory researches the mammalian mitochondrial electron transport chain (MtETC) and H+-ATP synthase, which together constitute the oxidative phosphorylation (OXPHOS) system.
This system as a functional entity and it is very important to know its role in health and disease. It is particularly interesting the role of the OXPHOS system in the development of the cardiovascular system, its relevance to ischemia-reperfusion, and its influence on microvascular blood flow.
Currently very little is known about why, where and how impaired function of the OXPHOS system manifests in disease. One reason for this is that there are major deficiencies in the established models of the organization of the electron transport chain. Thus the main lesson from research to date into human OXPHOS diseases is that our basic understanding is far from complete. In order to fill this gap, this group is implementing high-throughput strategies to catalogue the set of the genes whose products participate in the biogenesis and regulation of the OXPHOS system (the OXPHOME). We are also determining the factors that regulate the structural organization of the electron transport chain and the role that this superstructural organization plays in the production of reactive oxygen species (ROS). This area is linked to the role of ROS as mitochondrial second messengers and to the aim to deconstruct, in cellular models, the mammalian OXPHOS system into its functional components (electron transport, proton pumping and ATP synthesis).
Recent Publications
- Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing. Nature. 2016
- Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat Immunol 2016
- Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice.Sci Rep 2016 6:27351
- The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Cell Metab. 2016; 23(5):881-92
- Respiratory supercomplexes and the functional segmentation of the CoQ pool. Free Radic Biol Med. 2016
- Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016; 23(4):725-34.
- The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency. Cell Rep. 2016;15(1):197-209
- Mitochondrial Cristae: Where Beauty Meets Functionality. Trends Biochem Sci. 2016; 41(3):261-73
- Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses. Cell Metab. 2015; 22(3):485-98.
- HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages. Arterioscler Thromb Vasc Biol. 2015; 35(6):1463-71.
Address IP Jose Antonio Enriquez 914531200 Ext 2309 (This email address is being protected from spambots. You need JavaScript enabled to view it. Melchor Fernandez Almagro, 3. 28029 Madrid
Links (1) http://www.itn-meet.org (2) http://vmbacterio.cbm.uam.es/mitolab